New 5-oxomilbemycins from a Genetically Engineered Strain Streptomyces bingchenggensis BCJ60
نویسندگان
چکیده
Two new 5-oxomilbemycins, 27-aldehyde-5-oxomilbemycin β12 (1) and 2-hydroxymilbemycin K (2), were isolated from a genetically engineered strain Streptomyces bingchenggensis BCJ60. Their structures were determined by comprehensive analyses of its 1 H and 13 C NMR, COSY, HMQC, and HMBC spectroscopic, HRESI-MS mass spectrometric and comparison with data from the literature. Preliminary studies showed that 27aldehyde-5-oxomilbemycin β12 (1) and 2-hydroxymilbemycin K (2) possessed strong acaricidal and nematocidal activities.
منابع مشابه
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.
Streptomyces bingchenggensis is a soil-dwelling bacterium producing the commercially important anthelmintic macrolide milbemycins. Besides milbemycins, the insecticidal polyether antibiotic nanchangmycin and some other antibiotics have also been isolated from this strain. Here we report the complete genome sequence of S. bingchenggensis. The availability of the genome sequence of S. bingchengge...
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